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Summary:

  • Hevylite® assays can be run on the Binding Site SPAPLUS® and Optilite® analyser and the Siemens BNII analysers.
  • IgM Hevylite assays have in-built prozone parameters.

Immunoglobulin heavy/light chain immunoassays (Hevylite®; HLC) assays are available for the Binding Site SPAPLUS and Optilite analysers and the Siemens BNII. General features of Binding Site instruments are discussed in Chapter 37. Whilst IgGκ, IgGλ, IgAκ and IgAλ Hevylite assays are antisera-based assays, IgMκ and IgMλ Hevylite assays are latex-enhanced immunoassays, with in-built prozone parameters. The development of Hevylite assays, normal ranges, and implementation and interpretation are covered in Chapters 9, 10 and 11, respectively.