Up to 5% of patients presenting with solitary plasmacytomas go on to develop multiple lesions in the bone or elsewhere, without evidence of MM . The criteria for diagnosing patients with multiple solitary plasmacytomas are shown below. As with solitary plasmacytoma, sFLC measurements may be helpful in managing these patients.
|Criteria for the diagnosis of multiple solitary plasmacytomas (± recurrent) |
▪ Low concentration or absence of monoclonal protein in serum and/or urine
▪ More than one localised area of bone destruction or extramedullary tumour of clonal plasma cells, which may be recurrent
▪ Normal bone marrow
▪ Normal skeletal survey and MRI of spine and pelvis if done
▪ No related organ or tissue impairment (no end organ damage other than the localised bone lesions)